Spello combines its medieval aspect of winding streets and ancient stone houses with numerous Roman remains: such as the town walls used as the base for the medieval walls; the remains of a theatre, an amphitheatre, public baths; and the so-called Arco Augusto, ancient town entry gate. The historical town centre is still encircled by walls erected in 1360 taking in part of the Roman walls and three splendid gates: Porta Consolare (1st century BC), Porta Urbica and Porta Venere from the Augustan era, constructed with a triumphant arch, and on either side the 12-sided towers of Properzio. Some of the most remarkable religious buildings are the church of Santa Maria Maggiore (12th – 13th century), with great art works inside: to the left of the nave is the splendid Cappella Baglioni frescoed by Pintoricchio, as well as paintings by Perugino there is an ancient majolica flooring from Deruta (1516). Pintoricchio also executed the large panel of the Madonna e Santi (1508) in the 13th-century church of Sant’Andrea, which also contains the Crocifisso by the school of Giotto, and the body of Blessed Andrea Caccioli, companion of Saint Francis.
Apart from the Palazzo Comunale (Palazzo Cruciani), town hall housing the library, Historical Archives and Accademy of Costantinian Studies; also worthy of a visit are the Palazzo Baglioni (1358), Palazzo dei Canonici, home to the Pinacoteca, art gallery; and the church of San Lorenzo (12th century), where there is a precious marble tabernacle sculpted by Flaminio Vacca (1587)